Real-World Evidence: The Introduction
The late 1990s and early 2000s saw the widespread adoption of electronic health records (EHRs), which made the vast amounts of real-world patient data much more accessible to researchers. At the same time, the limitations of the classic Randomized Controlled Trials (RCT) were becoming more and more apparent: the highly controlled conditions of these trials did not always reflect the real-world usage of interventions, and their strict inclusion/exclusion criteria lead to study populations that did not represent the full diversity of patient groups who will ultimately use the drug. And with the rising healthcare costs, the need to demonstrate the value of new treatments in the real-world setting became increasingly important.
The emergence of Real-World Data (RWD) and Real-World Evidence (RWE) concepts has revolutionized how drug efficacy and safety are evaluated, how clinical trials are designed, and how healthcare decisions are made. In this note, we will cover the definitions, applications, and implications of RWD and RWE in pharmaceutical research.